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123871 Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem

123871
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Panoramica

Replacement Information

Products

Numero di catalogoConfezionamento Qtà/conf
123871-25MG Bottiglia di vetro 25 mg
Description
OverviewA cell-permeable and blood-brain barrier permeant HA14-1 (Cat. No. 371971) analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO model (40 mg/kg, i.p.) in vivo.
Catalogue Number123871
Brand Family Calbiochem®
SynonymsEthyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
References
ReferencesJo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.
Product Information
CAS number305834-79-1
FormOff-white solid
Hill FormulaC₁₇H₁₇ClN₂O₅
Chemical formulaC₁₇H₁₇ClN₂O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPleckstrin homology (PH) domain of Akt
Purity≥98% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and immediately freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
123871

Riferimenti bibliografici

Panoramica delle referenze
Jo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-November-2013 JSW
SynonymsEthyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
DescriptionA cell-permeable and blood-brain barrier permeant bromo-to-chloro substituted HA14-1 (Cat. No. 371971) analog that renders Akt in a conformation susceptible to phosphorylation by upstream kinases via specific interaction with Akt pleckstrin homology (PH) domain PtdIns(3,4,5)P3- (PIP3) binding pocket. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473) in a time- and dose-dependent manner (2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO (middle cerebral artery occlusion) model (40 mg/kg, i.p.) in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number305834-79-1
Chemical formulaC₁₇H₁₇ClN₂O₅
Structure formulaStructure formula
Purity≥98% by HPLC (sum of two isomers)
SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and immediately freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Toxicity Standard Handling
ReferencesJo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.