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MABT42 Anti-Integrin beta-2 (CD18) Antibody, clone M18/2

This Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18).

Anti-Integrin beta-2 (CD18) Antibody, clone M18/2: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: CD18, LFA-1, MAC-1, CD18, MF17, MFI7, LCAMB, LAD2 UniProt Number: P11835
MABT42
100 µg  
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Tabella delle specifiche principali

Species ReactivityKey ApplicationsHostFormatAntibody Type
MFC, IPRPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT42
DescriptionAnti-Integrin beta-2 (CD18) Antibody, clone M18/2
Alternate Names
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • integrin beta chain, beta 2
  • complement receptor C3 beta-subunit
  • leukocyte cell adhesion molecule CD18
  • integrin beta-2
  • Complement receptor C3 subunit beta
  • Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
  • CD18 antigen
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
  • macrophage antigen 1 (mac-1) beta subunit)
  • cell surface adhesion glycoprotein (LFA-1,CR3,P150,959 beta subunit precursor)
  • cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
Background InformationIntegrin beta-2, also known as CD18, is an adhesion receptor in neutrophils that interacts with cytohesin-1 intracellularly. Integrin beta is instrumental in activation-dependent adhesion and adhesion-dependent signaling. Expression of integrin beta-2 has a positive correlation with patient survival from malignant B cell lymphoma.
References
Product Information
FormatPurified
Control
  • Mouse EL4 cells
PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18).
Key Applications
  • Flow Cytometry
  • Immunoprecipitation
Application NotesImmunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Sanchez-Madrid, F., et al. (1983). J. ExP. MED. 158:586-602).

Inhibition Analysis: A previous lot of this antibody was shown to inhibit lymphoma metastasis (Zahalka, M. A. et al. (1993) J. Immunol. 150, 4466).
Biological Information
ImmunogenWhole B10 mouse spleen cells enriched with T-cells.
Cloneclone M18/2
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRat
IsotypeIgG2aκ
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CD18
  • LFA-1
  • MAC-1
  • CD18
  • MF17
  • MFI7
  • LCAMB
  • LAD2
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9 (By similarity).

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.

Contains 1 VWFA domain.
Molecular Weight85 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Flow Cytometry in mouse EL4 cells.

Flow Cytometry Analysis: 10 µg of this antibody detected Integrin beta-2 in mouse EL4 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numero di catalogo GTIN
MABT42 04053252681820

Documentation

Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 MSDS

Titolo

Scheda di sicurezza (MSDS) 

Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 Certificati d'Analisi

TitoloNumero di lotto
Anti-Integrin beta-2 (CD18), -2651947 2651947
Anti-Integrin beta-2 (CD18), -2676674 2676674
Anti-Integrin beta-2 (CD18), clone M18/2 - 2069386 2069386
Anti-Integrin beta-2 (CD18), clone M18/2 - 2279566 2279566
Anti-Integrin beta-2 (CD18), clone M18/2 - 3268925 3268925
Anti-Integrin beta-2 (CD18), clone M18/2 - 4096892 4096892
Anti-Integrin beta-2 (CD18), clone M18/2 - NRG1833256 NRG1833256
Anti-Integrin beta-2 (CD18), clone M18/2 Monoclonal Antibody 2979597