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204882 Complement C2, Human

204882
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Products

Numero di catalogoConfezionamento Qtà/conf
204882-50UG Fiala di plastica 50 μg
Description
OverviewNative, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.
Catalogue Number204882
Brand Family Calbiochem®
References
ReferencesAttwood, J.T., et al. 2001. Acta Paediatr. 90, 99.
Product Information
Activity≥4 × 10⁵ C₂H₅0 units/mg; ≥70% of the C2 activity in normal human serum on a mg/mg basis
FormLiquid
FormulationIn PBS, pH 6.0.
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by SDS-PAGE
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
ContaminantsC1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin:
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Complement C2, Human MSDS

Titolo

Scheda di sicurezza (MSDS) 

Complement C2, Human Certificati d'Analisi

TitoloNumero di lotto
204882

Riferimenti bibliografici

Panoramica delle referenze
Attwood, J.T., et al. 2001. Acta Paediatr. 90, 99.

Citazioni

Titolo
  • Inal J.M., and Schifferli, J.A., (2002) Journal of Immunology 168, 5213.
  • Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision27-May-2008 RFH
    DescriptionNative, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.
    FormLiquid
    FormulationIn PBS, pH 6.0.
    Concentration Label Please refer to vial label for lot-specific concentration
    SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
    Purity≥90% by SDS-PAGE
    ContaminantsC1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin:
    Activity≥4 × 10⁵ C₂H₅0 units/mg; ≥70% of the C2 activity in normal human serum on a mg/mg basis
    Storage ≤ -70°C
    Avoid freeze/thaw
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
    Toxicity Standard Handling
    ReferencesAttwood, J.T., et al. 2001. Acta Paediatr. 90, 99.
    Citation
  • Inal J.M., and Schifferli, J.A., (2002) Journal of Immunology 168, 5213.