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361556 GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem

361556
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₇H₁₂BrN₃O₂ 710323-61-8

Products

Numero di catalogoConfezionamento Qtà/conf
361556-1MG Fiala di plastica 1 mg
Description
OverviewA cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
Catalogue Number361556
Brand Family Calbiochem®
Synonyms1-Methyl-BIO
References
ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
Product Information
CAS number710323-61-8
ATP CompetitiveN
FormDark red solid
Hill FormulaC₁₇H₁₂BrN₃O₂
Chemical formulaC₁₇H₁₂BrN₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRelevant kinase inactive control
Primary Target IC<sub>50</sub>> 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
361556

Riferimenti bibliografici

Panoramica delle referenze
Knockaert, M., et al. 2004. Oncogene 23, 4400.
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms1-Methyl-BIO
DescriptionA cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC50 >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
FormDark red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number710323-61-8
Chemical formulaC₁₇H₁₂BrN₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.