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407711 Interleukin-12, Human, Recombinant, S. frugiperda

407711
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Products

Numero di catalogoConfezionamento Qtà/conf
407711-5UG Fiala di plastica 5 μg
Description
OverviewRecombinant, human interleukin-12 expressed in S. frugiperda insect cells. Pleiotropic cytokine that is produced by monocytes/macrophages, B cells, and connective tissue-type mast cells. Also known as natural killer cell stimulatory factor and cytotoxic lymphocyte maturation factor. A potent inducer of IFN-γ production and T cell differentiation and function.
Catalogue Number407711
Brand Family Calbiochem®
SynonymsrhIL-12
References
ReferencesKang, K., et al. 1996. J. Immunol. 156, 1402.
Riemann, H., et al. 1996. J. Immunol. 156, 1799.
Brunda, M.J., et al. 1994. J. Leukoc. Biol. 55, 280.
Smith, T.J., et al. 1994. Eur. J. Immunol. 24, 822.
Gubler, U., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4143.
Stern, A.S., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6808.
Kobayashi, M., et al. 1989. J. Exp. Med. 170, 827.
Product Information
FormLyophilized
FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-12.
Quality LevelMQ100
Applications
Biological Information
Biological activityED₅₀ = 50-200 pg/ml as measured by its ability to stimulate the proliferation of PHA-activated human lymphoblasts
Purity≥95% by SDS-PAGE
Physicochemical Information
ContaminantsEndotoxin: ≤1.0 EU/µg IL-12
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Interleukin-12, Human, Recombinant, S. frugiperda MSDS

Titolo

Scheda di sicurezza (MSDS) 

Interleukin-12, Human, Recombinant, S. frugiperda Certificati d'Analisi

TitoloNumero di lotto
407711

Riferimenti bibliografici

Panoramica delle referenze
Kang, K., et al. 1996. J. Immunol. 156, 1402.
Riemann, H., et al. 1996. J. Immunol. 156, 1799.
Brunda, M.J., et al. 1994. J. Leukoc. Biol. 55, 280.
Smith, T.J., et al. 1994. Eur. J. Immunol. 24, 822.
Gubler, U., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4143.
Stern, A.S., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6808.
Kobayashi, M., et al. 1989. J. Exp. Med. 170, 827.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-July-2008 RFH
SynonymsrhIL-12
DescriptionRecombinant, human interleukin-12 expressed in S. frugiperda insect cells. Pleiotropic cytokine that is produced by monocytes/macrophages, B-cells, and connective tissue type mast cells. Also known as natural killer cell stimulatory factor and cytotoxic lymphocyte maturation factor. A potent inducer of IFN-γ production and T-cell differentiation and function.
FormLyophilized
FormulationLyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-12.
Purity≥95% by SDS-PAGE
ContaminantsEndotoxin: ≤1.0 EU/µg IL-12
Biological activityED₅₀ = 50-200 pg/ml as measured by its ability to stimulate the proliferation of PHA-activated human lymphoblasts
SolubilityReconstitute to a concentration ≥1 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.
Storage ≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesKang, K., et al. 1996. J. Immunol. 156, 1402.
Riemann, H., et al. 1996. J. Immunol. 156, 1799.
Brunda, M.J., et al. 1994. J. Leukoc. Biol. 55, 280.
Smith, T.J., et al. 1994. Eur. J. Immunol. 24, 822.
Gubler, U., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4143.
Stern, A.S., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6808.
Kobayashi, M., et al. 1989. J. Exp. Med. 170, 827.