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Merck

74564

Trifluoroacetic acid

analytical standard

Synonym(s):

TFA

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About This Item

Linear Formula:
CF3COOH
CAS Number:
76-05-1
Molecular Weight:
114.02
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329764996
EC Number:
200-929-3
Beilstein/REAXYS Number:
742035
MDL number:
MFCD00004169

Key Documents

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InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

SMILES string

OC(C(F)(F)F)=O

grade

analytical standard

vapor density

3.9 (vs air)

vapor pressure

97.5 mmHg ( 20 °C)

assay

≥99.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤0.05% water

refractive index

n20/D 1.3 (lit.)

bp

72.4 °C (lit.)

mp

−15.4 °C (lit.)

solubility

H2O: soluble

density

1.489 g/mL at 20 °C (lit.)

application(s)

environmental

format

neat

Quality Level

100

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General description

Trifluoroacetic acid is a phytotoxic compound belonging to the class of perfluorinated acids (PFAs). It is an environmental contaminant, which contributes to the organo-fluorine burden in surface and ground waters.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Trifluoroacetic acid may be used as a modifier in high performance liquid chromatography mobile phase for protein and peptide separation due to its properties like chromatographic selectivity, high volatility and low ultraviolet light cut-off.
Trifluoroacetic acid may be used as an analytical reference standard for the determination of the analyte in water matrices using high-performance liquid chromatography coupled to tandem mass spectrometry.
Trifluoroacetic acid may be used as a modifier in high performance liquid chromatography mobile phase for protein and peptide separation due to its properties like chromatographic selectivity, high volatility and low ultraviolet light cut-off.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8A - Combustible corrosive hazardous materials

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

74564-10ML-F: + 74564-5ML-F: + 74564-VAR-F: + 74564-BULK-F: + 74564-1ML-F:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2173
BCCN2106
BCCL3366
BCCJ8301
BCCK8436

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Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases
Apffel A, et al.
Journal of Chromatography A, 712(1), 177-190 (1995)
Analysis of trifluoroacetic acid and other short-chain perfluorinated acids (C2--C4) in precipitation by liquid chromatography-tandem mass spectrometry: Comparison to patterns of long-chain perfluorinated acids (C5--C18)
Taniyasu S, et al.
Analytica Chimica Acta, 619(2), 221-230 (2008)
Yukiko Enomoto-Rogers et al.
Carbohydrate polymers, 92(2), 1827-1834 (2013-02-13)
Fully substituted glucomannan triacetate (GMTAc) (degree of substitution (DS)=3.0) was prepared from konjac glucomannan (KGM) treated with acetic acid and trifluoroacetic anhydride (TFAA). The peaks in the (1)H- and (13)C NMR spectra of GMTAc were assigned in detail based on
Caroline Le Maréchal et al.
Veterinary research, 42, 35-35 (2011-02-18)
Staphylococcus aureus is a major cause of mastitis in ruminants. In ewe mastitis, symptoms range from subclinical to gangrenous mastitis. S. aureus factors or host-factors contributing to the different outcomes are not completely elucidated. In this study, experimental mastitis was
Oskar Karlsson et al.
Archives of toxicology, 89(3), 423-436 (2014-05-07)
The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) has been implicated in the etiology of neurodegenerative disease, and recent studies indicate that BMAA can be misincorporated into proteins. BMAA is a developmental neurotoxicant that can induce long-term learning and memory deficits, as well
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