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Chromatin Associated Proteins

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Featured Antibody
Anti-E3 ubiquitin-protein ligase UHRF1 Antibody, clone 7C8

Merck:/Freestyle/BI-Bioscience/Antibodies-Assays/anti-e3-ubiquitin.jpg
HeLa cells were stained using Anti-E3 ubiquitin-protein ligase UHRF1, clone 7C8 (Cat. No MABE945, green). Actin filaments have been labeled with phalloidin (red). Nuclei are stained with DAPI (blue). This antibody positively stains the nucleus.
Chromatin is a complex molecule that can be found in either an open decondensed or active state (euchromatin) or in a tightly compacted inactive state (heterochromatin). The degree of compaction can be dynamic and is believed to be largely dependent on a variety of chromatin remodeling proteins that influence its structure and gene expression. A variety of histone modification enzymes (histone writers and erasers) impact histones, nucleosomes and the structure of chromatin. These proteins along with the various non-histone proteins modulate chromatin structure and influence the epigenetic regulation of a wide variety of genes.

Antibodies for Chromatin Analysis

Merck is a leading manufacturer and supplier of antibodies to study chromatin associated proteins enabling chromatin analysis. We offer a range of antibodies against histone modifying enzymes, chromatin remodeling complexes, transcriptional regulators, and other chromatin antibodies.

Merck offers a wide selection of antibodies with proven performance in applications such as chromatin immunoprecipitation (ChIP), as well as standard applications such as Western Blotting and immunocytochemistry. Look at the tables below to browse our selection of histone modifiers and chromatin reader antibodies or use our antibody search tool to find the exact antibody you need.

Browse Our Portfolio to Find Chromatin Assembly and Remodeling Protein Targets