124005 Akt Inhibitor - Calbiochem

124005
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概要

Replacement Information

主要スペック表

Empirical Formula
C₃₀H₅₈O₁₀

価格&在庫状況

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124005-1MGCN
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      樹脂アンプル 1 mg
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      Description
      OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
      Catalogue Number124005
      Brand Family Calbiochem®
      Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
      References
      ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.
      Product Information
      ATP CompetitiveY
      FormWhite to off-white solid
      Hill FormulaC₃₀H₅₈O₁₀
      Chemical formulaC₃₀H₅₈O₁₀
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationThis Akt inhibitor is a cell-permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (IC50 of 5.0 µM).
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>5.0 µM for Akt (PKB)
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Inhibitor - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Akt Inhibitor - Calbiochem 試験成績書(CoA)

      タイトルロット番号
      124005

      参考資料

      参考資料の概要
      Hu, Y., et al. 2000 J. Med. Chem. 43, 3045.

      カタログ

      タイトル
      Akt
      Biologics 31.1
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-June-2011 JSW
      Synonyms1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
      DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1-10 µM range.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₅₈O₁₀
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (200 mg/ml). Use anhydrous DMSO for reconstitution.
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesHu, Y., et al. 2000 J. Med. Chem. 43, 3045.