MABC171 Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1

MABC171
200 µL  
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      概要

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC171
      DescriptionAnti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1
      Alternate Names
      • Isocitrate dehydrogenase [NADP] cytoplasmic
      • IDH
      • Cytosolic NADP-isocitrate dehydrogenase
      • IDP
      • NADP(+)-specific ICDH
      • Oxalosuccinate decarboxylase
      Background InformationIsocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in various types of glioma.
      References
      Product Information
      FormatPurified
      Control
      • MBP tagged recombinant Isocitrate Dehydrogenase 1 (IDH1)
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect Isocitrate Dehydrogenase 1 (IDH1)-R132H using this Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1 validated for use in Western Blotting, IHC, ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesWestern Blot Analysis: A representative lot of this antibody detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in a panel of wild-type and mutated recombinant IDH1 proteins.

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in anaplastic and diffuse astrocytoma tissues and in primary glioblastoma tissues (Kato, Y., et al. (2009). Biochem Biophys Res Commun. 390(3):547-51.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in transfected glioblastoma and transfected LN229 cells (Kaneko, M. K., et al. (2011). Biochem Biophys Res Commun. 406(4):608-613.).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Isocitrate Dehydrogenase 1 (IDH1).
      CloneHMab-1
      HostMouse
      SpecificityThis antibody is specific for the R132H mutation of Isocitrate Dehydrogenase 1 (IDH1).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IDH1
      • PICD
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~90 kDa observed. The calculated molecular weight of Isocitrate Dehydrogenase 1 (IDH1) is 47 kDA. However, a Western Blot was performed using an MBP-tagged recombinant Isocitrate Dehydrogenase 1 (IDH1). Because MBP has a molecular weight of ~42 kDa, a band was observed at ~90 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in MBP-tagged recombinant Isocitrate Dehydrogenase 1 (IDH1).

      Western Blot Analysis: A 1:500 dilution of this antibody detected MBP tagged recombinant Isocitrate Dehydrogenase 1 (IDH1) in WB.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      試験成績書(CoA)

      タイトルロット番号
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 - 23701952370195
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 - 23883442388344
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 - 24368042436804
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 - 24524742452474
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 - 22721632272163
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 - 30655563065556
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 - Q2058409Q2058409
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 -25043212504321
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 -25526492552649
      Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H, clone HMab-1 -26048452604845

      参考資料

      参考資料の概要Pub Med ID
      Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.
      Santagata, S; Eberlin, LS; Norton, I; Calligaris, D; Feldman, DR; Ide, JL; Liu, X; Wiley, JS; Vestal, ML; Ramkissoon, SH; Orringer, DA; Gill, KK; Dunn, IF; Dias-Santagata, D; Ligon, KL; Jolesz, FA; Golby, AJ; Cooks, RG; Agar, NY
      Proceedings of the National Academy of Sciences of the United States of America  111  11121-6  2014

      概要を表示する
      24982150 24982150
      Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation.
      Kaneko, Mika Kato, et al.
      Biochem. Biophys. Res. Commun., 406: 608-13 (2011)  2011

      概要を表示する
      21352804 21352804
      A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation.
      Kato, Yukinari, et al.
      Biochem. Biophys. Res. Commun., 390: 547-51 (2009)  2009

      概要を表示する
      19818334 19818334

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies