14-306-M
GSK3β Protein, active, 10 µg
Active, N-terminal His6-tagged recombinant human GSK3β with an H350L mutation, for use in Kinase Assays.
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この商品について
UNSPSC Code:
12352202
NACRES:
NA.26
eCl@ss:
32160405
Form:
liquid
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Mol wt:
Mw 51 kDa
biological source
human
Quality Segment
recombinant
expressed in baculovirus infected Sf21 cells
form
liquid
mol wt
Mw 51 kDa
composition
mercaptoethanol, 0.1-1% , saccharose, 5-10%
manufacturer/tradename
Upstate®
storage condition
(Tightly closed)
technique(s)
activity assay: suitable (kinase)
solubility
water: soluble
NCBI accession no.
UniProt accession no.
Gene Information
human ... GSK3B(2932)
General description
Glycogen synthase kinase 3β (GSK3β) is a serine-threonine kinase that is present in most eukaryotes. The GSK3β gene is located on the human chromosome at 3q13.3. GSK3β is made up of an N-terminal β-sheet domain that is coupled to the C-terminal α-helical domain.
Research area: Cell Signaling
Research area: Cell Signaling
Biochem/physiol Actions
Glycogen synthase kinase 3β (GSK3β) regulates glycogen metabolism via an insulin-dependent pathway. It participates in many signaling pathways including cellular processes such as cell cycle, cell proliferation, and inflammation. GSK3β mediated-negative regulation of insulin signaling pathway leads to type 2 diabetes. GSK3β functions as a tumor suppressor that represses neoplastic transformation in cells. It is an essential regulator of the Wnt/β-catenin signaling pathway. Abnormal regulation of GSK3β is associated with cardiovascular disease, bipolar disorder, and neurodegenerative diseases.
Packaging
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-306M when ordering the 250μg size.
Analysis Note
Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
保管分類
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Deleterious substance
pdsc
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 14-306 | 04053252409486 |
| 14-306M | 04053252370427 |