8.51013
HATU
for peptide synthesis, Novabiochem®
別名:
HATU, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide
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この商品について
実験式（ヒル表記法）:
C10H15N6O · F6P
CAS番号:
分子量:
380.23
UNSPSC Code:
12352107
NACRES:
NA.22
MDL number:
製品名
HATU, Novabiochem®
Quality Segment
product line
Novabiochem®
form
solid
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
186 °C (decomposes)
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
[n]1(nnc2c1nccc2)[O+]=C(N(C)C)N(C)C
InChI
1S/C10H15N6O/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9/h5-7H,1-4H3/q+1
InChI key
WXIONIWNXBAHRU-UHFFFAOYSA-N
General description
A highly efficient coupling reagent for solid and solution phase peptide synthesis. In comparative studies HATU has been found to give better coupling yields with less enantiomerization that HBTU, TBTU or PyBOP®[1,2,3]. It is particularly effective at coupling to N-alkyl amines where other coupling reagents give poor yields and is the preferred reagent for loading resins bearing secondary amino groups.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] L. A. Carpino (1993) J. Am. Chem. Soc., 115, 4397.
[2] F. Albericio, et al. (1998) J. Org. Chem., 63, 9678.
[3] J. A. Carpino, et al., in "Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium", R. Epton (Ed.), Mayflower Worldwide Ltd., 1994, pp. 95.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] L. A. Carpino (1993) J. Am. Chem. Soc., 115, 4397.
[2] F. Albericio, et al. (1998) J. Org. Chem., 63, 9678.
[3] J. A. Carpino, et al., in "Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium", R. Epton (Ed.), Mayflower Worldwide Ltd., 1994, pp. 95.
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Identity (NMR, 1H): passes test
Solubility (1 mmole in 2 ml DMF): clearly soluble
Appearance of substance (visual): powder
Identity (IR): passes test
Identity (NMR, 1H): passes test
Solubility (1 mmole in 2 ml DMF): clearly soluble
Other Notes
Replaces: 01-62-0041
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany
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Danger
保管分類
4.1A - Other explosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
supp_hazards
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1A