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Merck

07-590

Anti-Ago 2 Antibody

Upstate®, from rabbit

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
23

主要文書

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biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NP_036286.2

UniProt accession no.

Q9UKV8

shipped in

ambient

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... AGO2(27161)

General description

100 kDa
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing.

Provides endonuclease activity to RNA-induced silencing complexes (RISC). Cleaves siRNA/mRNA heteroduplexes bound to RISC. Essential for embryonic development as well as RNA-mediated gene silencing (RNAi).

Immunogen

GST fusion protein corresponding to residues 7-48 of human argonaute 2 (Ago2).

Application

Anti-Ago 2 Antibody is a Rabbit Polyclonal Antibody for detection of Ago 2 also known as argonaute 2 & has been tested in WB.

Biochem/physiol Actions

Recognizes Ago 2, also known as eukaryotic translation initiation factor 2C, 2 (EIF2C 2), MGC3183 and Q10.

Physical form

Format: Purified

Analysis Note

Control
HeLa cell lysate, HL-60 cell lysate
Routinely evaluated by immunoblot in RIPA and cytosolic lysates from HeLa cells.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類

10 - Combustible liquids

wgk

WGK 1

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

07-590-25UG: + 07-590:

jan

試験成績書（COA）

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Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis.
Lund, E; Sheets, MD; Imboden, SB; Dahlberg, JE
Genes & Development null
Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
Farazi, TA; Ten Hoeve, JJ; Brown, M; Mihailovic, A; Horlings, HM; van de Vijver et al.
Genome Biology null
Kumi Sakurai et al.
Nucleic acids research, 39(4), 1510-1525 (2010-10-26)
RNA interference is a powerful mechanism for sequence-specific inhibition of gene expression. It is widely known that small interfering RNAs (siRNAs) targeting the same region of a target-messenger RNA can have widely different efficacies. In efforts to better understand the
Xiao-Yu Zhang et al.
Molecular cancer, 23(1), 113-113 (2024-05-28)
The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed in HCC cases through bioinformatics analysis. This study aimed to investigate the oncogenic properties and mechanisms of circPIAS1 in HCC development.
Takashi Sasaki et al.
Genomics, 82(3), 323-330 (2003-08-09)
A number of genes have been identified as members of the Argonaute family in various nonhuman organisms and these genes are considered to play important roles in the development and maintenance of germ-line stem cells. In this study, we identified
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関連コンテンツ

RNA-Binding Protein Immunoprecipitation

All eukaryotic organisms require tight regulation of gene expression for complex processes such as development, differentiation, cell specification, and responses to environmental stimuli. Many genes are regulated post-transcriptionally, in addition to transcriptional mechanisms of gene regulation. RNA-binding proteins (RBPs) are essential for post-transcriptional gene regulation, linking transcription and translation in many processes including transcription, splicing, export, rate of translation and turnover. In all of these events, RBPs coordinate regulation of the amount of protein produced from mRNA transcripts.

グローバルトレードアイテム番号

カタログ番号GTIN
07-590-25UG04054839342516

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