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Merck

07-838

Anti-phospho-IR (Tyr972) Antibody

Upstate®, from rabbit

別名:

Insulin Receptor, CD220

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
mouse, human
Application:
WB
Citations:
9
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biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

phosphorylation (pTyr972)

Quality Level

Gene Information

human ... INSR(3643)

General description

155 kDa

Immunogen

A linear peptide corresponding to amino acid region encompassing the human, mouse and rat phospho-IR (pTyr972).

Application

Anti-phospho-IR (Tyr972) Antibody detects level of phospho-IR (Tyr972) & has been published & validated for use in WB.
Research Category
Signaling
Research Sub Category
Insulin/Energy Signaling

Biochem/physiol Actions

Predicted to cross-react with rat based on sequence homology (100%), but have not been tested.
Recognizes phospho-IR (β-subunit) (pTyr972).

Physical form

100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide) and 50% glycerol.
Affinity purified

Preparation Note

Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

07-838:

jan


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Preparation, crystallization and preliminary X-ray analysis of threonine synthase from Streptococcus mutans.
De-Wei Tang,Lan-Fen Li,Ya-Mei Yu,Xiang-Yu Liu,Xiao-Dong Su,Xiaojun Zhao,Yu-He Liang
Protein and peptide letters null
Rebecca B Hughes et al.
Autism research : official journal of the International Society for Autism Research, 15(4), 614-627 (2022-02-11)
2p16.3 deletion, involving NEUREXIN1 (NRXN1) heterozygous deletion, substantially increases the risk of developing autism and other neurodevelopmental disorders. We have a poor understanding of how NRXN1 heterozygosity impacts on brain function and cognition to increase the risk of developing the
Vitor R Muñoz et al.
Journal of cellular physiology, 233(6), 4791-4800 (2017-12-09)
The effects of physical exercise on insulin signaling and glycemic homeostasis are not yet fully understood. Recent findings elucidated the positive role of Rho-kinase (Rock) in increasing the glucose uptake through insulin receptor substrate-1 (IRS1) phosphorylation in the skeletal muscle.
Renan Fudoli Lins Vieira et al.
The Journal of physiology, 600(4), 797-813 (2021-01-16)
Time-restricted feeding (TRF, in which energy intake is restricted to 8 h/day during the dark phase) alone or combined with aerobic exercise (AE) training can prevent weight gain and metabolic disorders in Swiss mice fed a high-fat diet. The benefits of
Marina C Muñoz et al.
The Journal of endocrinology, 201(2), 185-197 (2009-03-03)
The I kappaB kinase-beta (IKK-beta)/nuclear factor-kappaB signaling pathway has been suggested to link inflammation with obesity and insulin resistance. In addition, angiotensin (Ang) II is able to induce insulin resistance and an inflammatory state through Ang II receptor type 1

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カタログ番号GTIN
07-83804053252622496

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