1.01900
ジメチルスルホキシド
for headspace gas chromatography SupraSolv®
別名:
DMSO, メチルスルホキシド
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この商品について
化学式:
(CH3)2SO
CAS番号:
分子量:
78.13
UNSPSC Code:
12191502
NACRES:
NA.03
EC Index Number:
200-664-3
MDL number:
Beilstein/REAXYS Number:
506008
Assay:
≥99.8% (GC)
Technique(s):
GC-HS: suitable
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)
Quality Segment
agency
according to Ph. Eur., according to USP
vapor density
2.7 (vs air)
vapor pressure
0.42 mmHg ( 20 °C)
product line
SupraSolv®
assay
≥99.8% (GC)
form
liquid
autoignition temp.
573 °F
potency
28300 mg/kg LD50, oral (Rat), 40000 mg/kg LD50, skin (Rat)
expl. lim.
42 %, 63 °F
technique(s)
GC-HS: suitable
impurities
≤1 μg/g Every residual solvent of class 1 acc. to ICH, ≤10 μg/g Every residual solvent of class 2 acc. to ICH, ≤50 μg/g Every residual solvent of class 3 acc. to ICH, ≤0.05% Water
evapn. residue
≤3.0 mg/L
color
APHA: ≤10
refractive index
n
kinematic viscosity
2.14 cSt
bp
189 °C (lit.)
mp
16-19 °C (lit.)
transition temp
flash point 87 °C
density
1.10 g/mL (lit.)
storage temp.
2-30°C
SMILES string
CS(C)=O
InChI
1S/C2H6OS/c1-4(2)3/h1-2H3
InChI key
IAZDPXIOMUYVGZ-UHFFFAOYSA-N
General description
SupraSolv® for headspace gas chromatography (GC-HS) is a dedicated high-purity solvent grade specifically formulated to meet the stringent analytical demands of residual solvent determination in pharmaceutical active pharmaceutical ingredients (APIs), drug products, and other regulated matrices.In headspace GC, the solvent serves as the diluent medium in which the sample is dissolved prior to equilibrium partitioning of volatile analytes into the gaseous headspace phase for subsequent chromatographic injection. Consequently, the chemical purity of the solvent is of critical analytical importance: any residual volatile impurities intrinsic to the solvent matrix may co-elute with target analytes, generating false-positive signals or suppressing accurate quantification. SupraSolv® headspace solvents are therefore specifically developed and tested to contain extremely low concentrations of residual solvents, as mandated by regulatory guidelines.
Application
SupraSolv® headspace GC solvents are indispensable in pharmaceutical residual solvent testing, polymer and excipient quality control, food packaging safety assessment, and industrial material characterization — analytical contexts in which solvent purity is a direct regulatory and safety requirement, and where the integrity of trace-level volatile quantification is non-negotiable.
Features and Benefits
- Regulatory compliance with ICH Q3C, Ph. Eur., and USP residual solvent guidelines, directly supporting pharmaceutical quality control workflows
- Ultra-low intrinsic volatile impurity content, eliminating solvent-derived interferences in the headspace chromatogram and ensuring an unobstructed baseline
- Batch-to-batch consistency, ensuring reproducibility across analytical campaigns
Analysis Note
SupraSolv® headspace solvents adhere to the residual solvent classification thresholds defined by the International Council for Harmonisation (ICH Q3C) and referenced in pharmacopoeial standards (Ph. Eur. and USP), with certified limits including:
- Class 1 solvents (known human carcinogens / environmental hazards): ≤ 1 µg/g
- Class 2 solvents (non-genotoxic, dose-dependent toxicants): ≤ 10 µg/g
- Class 3 solvents (low toxic potential): ≤ 50 µg/g
Other Notes
Complete GC Workflow Guide for ICH Q3C(R9) and USP<467>Compliance
Explore various labsafety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.
Explore various labsafety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.
Legal Information
SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
容易に過冷却状態となり、室温で徐々に再融解します。凝固している場合は室温に放置すると、劣化させることなく液体に戻すことができます。
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保管分類
10 - Combustible liquids
引火点 (F)
188.6 °F - closed cup
引火点（°C）
87 °C - closed cup
適用法令
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第4類:引火性液体 + 第三石油類 + 危険等級III + 水溶性液体
fsl
1019000500: + 1019002500: + 1019001000: + 1019000501: + 1019000000: + 1019002508:
jan
名称等を表示すべき危険物及び有害物
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名称等を通知すべき危険物及び有害物
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