108975
Leupeptin, Hemisulfate, Microbial
Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases
別名:
Leupeptin, Hemisulfate, Microbial, Ac-LLR-CHO, ½H2SO4
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この商品について
実験式（ヒル表記法）:
C20H38N6O4 · 0.5H2SO4
CAS番号:
分子量:
475.59
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Assay:
≥90% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
SMILES string
[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O
InChI
1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
InChI key
GDBQQVLCIARPGH-ULQDDVLXSA-O
description
Merck USA index - 14, 5456
assay
≥90% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
Biochem/physiol Actions
Cell permeable: no
Primary Target
trypsin- and cysteine-like proteases
trypsin- and cysteine-like proteases
Product does not compete with ATP.
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Other Notes
Ac-Leu-Leu-arginal, hemisulfate
Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
108975-10MG: + 108975-MG: + 108975-15GM: + 108975-5MG: + 108975-200MG: + 108975-25MG: + 970733-250MG: + 108975-0MG: + 108975-50MG: + 108975-100MG: + 970733-MG: + 108975-1GM:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
John M Barbaro et al.
Journal of leukocyte biology, 112(5), 1317-1328 (2022-10-08)
HIV-associated neurocognitive impairment (HIV-NCI) is a debilitating comorbidity that reduces quality of life in 15-40% of people with HIV (PWH) taking antiretroviral therapy (ART). Opioid use has been shown to increase neurocognitive deficits in PWH. Monocyte-derived macrophages (MDMs) harbor HIV
Fang Wu et al.
Nature communications, 14(1), 6208-6208 (2023-10-06)
Lysine acetylation has been discovered in thousands of non-histone human proteins, including most metabolic enzymes. Deciphering the functions of acetylation is key to understanding how metabolic cues mediate metabolic enzyme regulation and cellular signaling. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme
Joel Vega-Badillo et al.
STAR protocols, 4(2), 102336-102336 (2023-06-04)
Binding affinity quantitatively describes the strength of a molecular interaction and is reported by the equilibrium dissociation constant (KD). Here, we present a protocol to measure KD of mammalian microRNA-loaded Argonaute2 protein by double filter binding. We describe steps for
Lisa Marquardt et al.
Autophagy, 19(1), 278-295 (2022-05-17)
The yeast PROPPIN Atg18 folds as a β-propeller with two binding sites for phosphatidylinositol-3-phosphate (PtdIns3P) and PtdIns(3,5)P2 at its circumference. Membrane insertion of an amphipathic loop of Atg18 leads to membrane tubulation and fission. Atg18 has known functions at the
Mohammad Haeri et al.
Methods in molecular biology (Clifton, N.J.), 884, 17-39 (2012-06-13)
Transgenesis, the process of incorporating an exogenous gene (transgene) into an organism's genome, is a widely used tool to develop models of human diseases and to study the function and/or regulation of genes. Generating transgenic Xenopus is rapid and involves
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 108975-100MGCN | 04055977208535 |
| 108975-5MGCN | 04055977208573 |
| 108975-25MGCN | 07790788047757 |
| 108975-10MGCN | 04055977208528 |
| 108975-50MGCN | 04055977208580 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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