119120
Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt
A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.
別名:
Adenosine 5′-O-(3-Thiotriphosphate), Tetralithium Salt, ATP-γ-S, 4Li
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
実験式（ヒル表記法）:
C10H12N5O12P3S · 4Li
CAS番号:
分子量:
546.98
UNSPSC Code:
12352208
NACRES:
NA.51
MDL number:
Form:
solid
Assay:
≥85% (HPLC)
Solubility:
water: 10 mg/mL
Color:
white
Quality Segment
assay
≥85% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
impurities
<10% ADP
color
white
solubility
water: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
[Li+].[Li+].[Li+].[Li+].[P](=O)([S-])([O-])O[P](=O)([O-])O[P](=O)([O-])OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)[n]2c3ncnc(c3nc2)N
InChI
1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
InChI key
DWQFDOIBOYDYKH-KWIZKVQNSA-J
General description
A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Increases the activity of Ca2+-activated K+ channels. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.
Application
- Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).
- Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.
Other Notes
Troadec, J.D., et al. 1999. Pflugers Arch. 437, 745.
Chung, S., et al. 1991. Science253, 560.
Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.
Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.
Chung, S., et al. 1991. Science253, 560.
Litosch, I., and Fain, J.N. 1986. Life Sci. 39, 187.
Chrysogelos, S., et al. 1983. J. Biol. Chem.258, 12624.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable