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Merck

14-602-M

PI3 Kinase (p110α/p85α) Protein, active, 20 µg

Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.

別名:

Active PI3 Kinase Protein, PI3 Kinase p110α/p85α

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この商品について

UNSPSC Code:
12352202
NACRES:
NA.26
eCl@ss:
32160405
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
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biological source

human

Quality Segment

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 125.3 kDa (p110α), Mw 83.7 kDa (p85α)

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

Gene Information

human ... PIK3CA(5290)

General description

Product Source: Coexpressed by baculovirus in Sf21 insect cells
Research area: Cell signaling

Protein Target: PI3Kα/p85α Target Sub-Family: PI3K/PI4K

Complex of N-terminal His6-tagged recombinant full-length human p110α and untagged, recombinant, full length, human p85α

Application

PI3 Kinase (p110α/p85α) Protein has been used in in vitro kinase assay.

Biochem/physiol Actions

Phosphoinositide 3-kinases (PI3Ks) are enzymes that play a crucial role in cell signaling. They are responsible for activating signaling pathways that regulate important cellular processes such as cell survival, proliferation, protein synthesis, cell metabolism, cytoskeletal rearrangements, and vesicle trafficking. PI3Ks exhibits both lipid kinase activity (phosphorylation of inositol ring in phosphatidylinositol (PtdIns) lipids) and protein kinase activity (including autophosphorylation).

Packaging

Also available in 250μg size as catalog # 14-602M - Call for pricing and availability.

Physical form

Ni2+/NTA-agarose

Preparation Note

6 months at -70°C

Analysis Note

routinely evaluated by PIProfiler

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.




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