165350
PARP Inhibitor I, 3-ABA
The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
別名:
PARP Inhibitor I, 3-ABA, 3-Aminobenzamide
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この商品について
Assay:
≥99% (GC)
Form:
solid
Storage condition:
OK to freeze
description
RTECS - CU8992000
Quality Segment
assay
≥99% (GC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
ethanol: 1 mg/mL, water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
Nc1cc(ccc1)C(=O)N
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
General description
A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PARP
PARP
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.
Other Notes
Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
保管分類
11 - Combustible Solids
wgk
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
165350-100MG: + 165350-MG: + 165350-1.1ML:
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