182690
AhR Agonist V, VAF347
The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.
å¥å:
AhR Agonist V, VAF347, (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
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å®éšåŒïŒãã«è¡šèšæ³ïŒ:
C17H11ClF3N3
CASçªå·:
ååé:
349.74
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.51
PubChem Substance ID:
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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ãæäŒãããŸãQuality Segment
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
C1=CC(=CC(=C1)Cl)C2=NC(=NC=C2)NC3=CC=C(C=C3)C(F)(F)F
InChI key
XTKUZTBZRIJTFR-UHFFFAOYSA-N
General description
A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
Packaging
Packaged under inert gas
Other Notes
Platzer, B., et al. 2009. J. Immunol.183, 66.
Hauben, E., et al. 2008. Blood118, 1214.
Lawrence, B.P., et al. 2008. Blood112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med.173, 599.
Hauben, E., et al. 2008. Blood118, 1214.
Lawrence, B.P., et al. 2008. Blood112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med.173, 599.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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11 - Combustible Solids
WGK
WGK 2
åŒç«ç¹ (F)
Not applicable
åŒç«ç¹ïŒÂ°CïŒ
Not applicable
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