200499
Bexarotene
≥96% (HPLC), retinoid X receptor agonist, powder
別名:
Bexarotene, 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
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この商品について
実験式（ヒル表記法）:
C24H28O2
CAS番号:
分子量:
348.48
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥96% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
製品名
Bexarotene, A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner.
Quality Segment
assay
≥96% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to orange
solubility
DMSO: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
SMILES string
OC(=O)c1ccc(cc1)C(=C)c2cc3c(cc2C)C(CCC3(C)C)(C)C
InChI
1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChI key
NAVMQTYZDKMPEU-UHFFFAOYSA-N
General description
A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.
Biochem/physiol Actions
Cell permeable: yes
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Cramer, P.E., et al. 2012. Science Exp.335, 1503.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
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保管分類
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable