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Merck

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2011

Bilirubin

solid, bile pigment, Calbiochem®

別名:

Bilirubin

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実隓匏ヒル衚蚘法:
C33H36N4O6
CAS番号:
635-65-4
分子量:
584.66
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00005499
Form:
solid
Storage condition:
OK to freeze, protect from light
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補品名

Bilirubin, Principal pigment of bile and one of the major end products of hemoglobin decomposition.

Quality Segment

description

RTECS - DU3038000
Merck USA index - 14, 1218

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

red-brown

solubility

chloroform: 1 mg/mL, alkaline solution: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

[nH]1c(c(c(c1\C=C4/NC(=O)C(=C/4C)C=C)C)CCC(=O)O)Cc2[nH]c(c(c2CCC(=O)O)C)\C=C3/NC(=O)C(=C/3C=C)C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

InChI key

BPYKTIZUTYGOLE-IFADSCNNSA-N

General description

Bilirubin is an orange-yellow bile pigment and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. In adults, the upper limit of the normal range of bilirubin is >1mg/dL. Serum levels of bilirubin in healthy newborns are less than 15 mg/dl. This product corresponds to the unconjugated form.

Biochem/physiol Actions

Bilirubin is reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This pigment aids in coloration in the various forms of jaundice. Bilirubin levels act as biomarkers in liver and blood disorders. Unconjugated form of bilirubin at lower levels serves as a physiological antioxidant. However, increased concentration of bilirubin is toxic and leads to neonatal hyperbilirubinemia in neonates.

Preparation Note

Unstable in basic solutions; reconstitute just prior to use.

Other Notes

Extinction coefficient (454 nm, CHCl3):59,100-62,300 M-1cm-1.
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Target

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類

11 - Combustible Solids

WGK

WGK 2

匕火点 (F)

Not applicable

匕火点°C

Not applicable

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