204882
Complement C2, Human
Complement C2, Human, is a native, single chain glycoprotein present. C2 is cleaved by the activated C1s into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment.
別名:
C2 Protein
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この商品について
NACRES:
NA.25
UNSPSC Code:
12352202
Quality Segment
assay
≥90% (SDS-PAGE)
form
liquid
specific activity
≥4×105 C2H50 units/mg (>=70% of the C2 activity in normal human serum on a mg/mg basis)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
impurities
C1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin, trace
shipped in
wet ice
storage temp.
−70°C
General description
Native, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In PBS, pH 6.0.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Other Notes
Attwood, J.T., et al. 2001. Acta Paediatr.90, 99.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
12 - Non Combustible Liquids
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適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
204882-50UG: + 204882-UG:
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