235135
Corticosterone
≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem
別名:
Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H
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この商品について
Assay:
≥95% (HPLC)
Form:
crystalline powder
Storage condition:
OK to freeze
製品名
Corticosterone, Corticosteroid hormone synthesized in response to stress.
Quality Segment
description
Merck USA index - 14, 2538
assay
≥95% (HPLC)
form
crystalline powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white, white to tan
solubility
ethanol: 50 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
General description
Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Mineralocorticoid and glucocorticoid receptors
Mineralocorticoid and glucocorticoid receptors
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
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保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 3