239819
CXCR2 antagonist, Cpd 19
The CXCR2 antagonist, Cpd 19, also referenced under CAS 473728-67-5, controls the biological activity of CXCR2.
別名:
CXCR2 antagonist, Cpd 19, 3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
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この商品について
実験式（ヒル表記法）:
C18H21N3O4
CAS番号:
分子量:
343.38
MDL number:
NACRES:
NA.51
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 50 mg/mL, light brown
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37°C).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
保管分類
11 - Combustible Solids
WGK
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable