324626
EGTA, Molecular Biology Grade
別名:
EGTA, Molecular Biology Grade, Ethyleneglycol- bis(β-aminoethyl)-N,N,Nʹ,Nʹ-tetraacetic Acid
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この商品について
実験式（ヒル表記法）:
C14H24N2O10
CAS番号:
分子量:
380.35
UNSPSC Code:
12352106
NACRES:
NA.25
MDL number:
grade
Molecular Biology
Quality Segment
description
RTECS - AH3760000
assay
≥98% dry basis (complexometric)
form
solid (fine)
reaction suitability
reagent type: chelator
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
1 M NaOH: soluble
cation traces
heavy metals (as Pb): ≤0.001%
foreign activity
DNases, proteases, RNases, none detected
shipped in
ambient
storage temp.
10-30°C
SMILES string
N(CCOCCOCCN(CC(=O)O)CC(=O)O)(CC(=O)O)CC(=O)O
InChI
1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
InChI key
DEFVIWRASFVYLL-UHFFFAOYSA-N
General description
Chelating agent selective for Ca2+. Binds one cation per molecule. Induces apoptosis in pheochromocytoma (PC12) cells.
Application
- Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.: This study presents a genetically encoded biosensor for real-time monitoring of lysosomal pH changes, potentially enhanced by buffering agents like EGTA. The findings may offer insights into cellular mechanisms influenced by calcium chelation (Ponsford et al., 2021).
- Comparative Proteomic Analysis of Pleurotus ostreatus Reveals Great Metabolic Differences in the Cap and Stipe Development and the Potential Role of Ca(2+).: The research highlights the role of calcium in fungal development, with EGTA potentially influencing these biological processes through calcium chelation (Zhu et al., 2019).
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
Other Notes
Lindenboim, L., et al. 1995. J. Neurochem.64, 1054.
Bers, D.M. 1982. Am. J. Physiol.242, C404.
Bers, D.M. 1982. Am. J. Physiol.242, C404.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
WGK
WGK 2