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324890

E-64 Protease Inhibitor

Name: E-64 Protease Inhibitor
Brand: MM

The E-64 Protease Inhibitor, also referenced under CAS 66701-25-5, controls the biological activity of E-64 Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

別名:

E-64 Protease Inhibitor, (2 R,3 R)-3-(( S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, L- trans-3-Carboxyoxira, (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, L-trans-3-Carboxyoxiran-R

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この商品について

実験式（ヒル表記法）:

C₁₅H₂₇N₅O₅

CAS番号:

66701-25-5

分子量:

357.41

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00080261

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特性

description

RTECS - RR0390000

Quality Segment

200

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

input

general use sample(s)

solubility

water: 20 mg/mL, DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

N([C@@H](CC(C)C)C(=O)NCCCCN\C(=N/[H])\N)C(=O)[C@@H]1O[C@H]1C(=O)O

InChI

1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10+,11+/m0/s1

InChI key

LTLYEAJONXGNFG-HBNTYKKESA-N

詳細

General description

Irreversible inhibitor of cysteine proteases. Interacts with the S_n subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Specific active site titrant.

Biochem/physiol Actions

Cell permeable: no

Primary Target
cysteine proteases

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Matsumoto, K., et al. 1999. Biopolymers51, 99.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J.201, 189.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

引火点 (F)

Not applicable

引火点（°C）