328500
ERO1 Inhibitor I, Erodoxin
The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1.
別名:
ERO1 Inhibitor I, Erodoxin, 1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor
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この商品について
実験式（ヒル表記法）:
C7H5BrN2O5
CAS番号:
分子量:
277.03
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL (Use only fresh DMSO)
shipped in
wet ice
storage temp.
2-8°C
SMILES string
BrC(C=C(C([N+]([O-])=O)=C1)OC)=C1[N+]([O-])=O
InChI
1S/C7H5BrN2O5/c1-15-7-2-4(8)5(9(11)12)3-6(7)10(13)14/h2-3H,1H3
InChI key
SYWWRIKZBWQUGY-UHFFFAOYSA-N
General description
A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC50 = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Costanzo, M., et al. 2010. Science327, 425.
Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993.
Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。