341209
EUK-8
A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.
別名:
EUK-8
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この商品について
実験式（ヒル表記法）:
C16H14ClMnN2O2
CAS番号:
分子量:
356.69
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (elemental analysis)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥90% (elemental analysis)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
dark brown
solubility
DMSO: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Mn+3].[Cl-].N(=C\c2c(cccc2)[O-])/CC\N=C\c1c(cccc1)[O-]
InChI
1S/C16H16N2O2.ClH.Mn/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;;/h1-8,11-12,19-20H,9-10H2;1H;/q;;+3/p-3/b17-11+,18-12+;;
InChI key
HBQGFROGWOHBAG-SNTCFBDDSA-K
General description
A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ40 and Aβ42 toxicity in hippocampal cultures.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities
Superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Other Notes
Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol.130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.
Legal Information
Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 2