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341610

FGF/PDGF/VEGF RTK Inhibitor

Name: FGF/PDGF/VEGF RTK Inhibitor
Brand: MM

The FGF/PDGF/VEGF RTK Inhibitor, also referenced under CAS 144335-37-5, controls the biological activity of FGF/PDGF/VEGF RTK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

別名:

FGF/PDGF/VEGF RTK Inhibitor, 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII, PDGFR Tyrosine Kinase Inhibitor XVII, 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII

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この商品について

実験式（ヒル表記法）:

C₁₆H₁₁N₃O₂

CAS番号:

144335-37-5

分子量:

277.28

MDL number:

MFCD00572729

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[nH]1c2c(nc1c3c(nc4c(c3O)cccc4)O)cccc2

InChI

1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)

InChI key

YXCWBNCDJZEBKY-UHFFFAOYSA-N

詳細

General description

A cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC₅₀ = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC₅₀ = 420 nM).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Renhowe, P.A., et al. 2009. J. Med. Chem.52, 278.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 2

引火点 (F)

Not applicable

引火点（°C）