344216
WKYMVm
≥95% (HPLC), Formyl Peptide Receptor-Like 1 Agonist, lyophilized
別名:
Formyl Peptide Receptor-Like 1 Agonist, WKYMVm, H₂N-WKYMV- D-M-CONH2, FPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH2, FPRL1 Agonist, WKYMVm
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この商品について
実験式（ヒル表記法）:
C41H61N9O7S2
分子量:
856.11
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
lyophilized
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
製品名
Formyl Peptide Receptor-Like 1 Agonist, WKYMVm, The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
Quality Segment
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
Biochem/physiol Actions
Primary Target
Formyl Peptide Receptor-Like 1
Formyl Peptide Receptor-Like 1
Product does not compete with ATP.
Reversible: no
EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
Cell permeable: no
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bae, Y.S., et al. 2004. J. Immunol.173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol.64, 841.
Le, Y., et al. 1999. J. Immunol.163, 6777.
Seo, J.K., et al. 1997. J. Immunol.158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem.271, 8170.
Bae, Y.S., et al. 2003. Mol. Pharmacol.64, 841.
Le, Y., et al. 1999. J. Immunol.163, 6777.
Seo, J.K., et al. 1997. J. Immunol.158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem.271, 8170.
H-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
344216-MG: + 344216-5MG:
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