344597
FTY720
別名:
2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl, FTY720
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この商品について
Form:
solid
Storage condition:
OK to freeze
form
solid
storage condition
OK to freeze
solubility
soluble (DMSO (20 mg/ml) or Ethanol (20 mg/ml))
storage temp.
−20°C
General description
A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).