344827
Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose
2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.
別名:
Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose, (3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate
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この商品について
実験式（ヒル表記法）:
C12H17FO7
分子量:
292.26
NACRES:
NA.77
UNSPSC Code:
12352111
製品名
Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose, 2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Fucosyltransferase
Fucosyltransferase
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.
Other Notes
Rillahan, C., et al. 2012.. Nat. Chem. Bio.8, 661.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Sarah Bui et al.
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グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 344827-10MGCN | 04055977214833 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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