345888
JMV 2959
≥97% (HPLC), powder, Ghrelin receptor antagonist, Calbiochem®
別名:
Ghrelin Receptor Antagonist, JMV 2959, Growth hormone secretagogue receptor antagonist, (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959
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この商品について
実験式（ヒル表記法）:
C30H32N6O2 · xHCl
分子量:
508.61 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
製品名
Ghrelin Receptor Antagonist, JMV 2959,
assay
≥97% (HPLC)
Quality Segment
form
powder
potency
32 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
DMSO: 100 mg/mL, water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
JMV 2959, which blocks the signaling of the growth hormone secretagogue receptor 1A, reduces the deficits in prepulse inhibition induced by the NMDAR antagonist, phencyclidine.
Application
Ghrelin Receptor Antagonist, JMV 2959 has been used to examine oxytocin receptor (OTR) and ghrelin receptor (GHSR) signaling. It has also been used as a GHS-R1a receptor antagonist to pretreat Hek cells followed by pyridone 8 exposure to study its effect on GHS-R1a receptor-mediated calcium influx.
Biochem/physiol Actions
Primary Target
Ghrelin receptor
Ghrelin receptor
Packaging
Packaged under inert gas
Physical form
Supplied as a hydrochloride salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Moulin, A., et al. 2013. Amino Acids44, 301.
Mary, S., et al. 2012. Proc Natl Acad Sci USA109, 8304.
Salome, N., et al. 2009. Eur J Pharmacol.612, 167,.
Moulin, A., et al. 2007. J Med Chem50, 579.
Mary, S., et al. 2012. Proc Natl Acad Sci USA109, 8304.
Salome, N., et al. 2009. Eur J Pharmacol.612, 167,.
Moulin, A., et al. 2007. J Med Chem50, 579.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 2
引火点 (F)
Not applicable
引火点（°C）
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
345888-10MG: + 345888-MG:
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