353905
Glutathione Monoethyl Ester
>90% (TLC), solid, GSH-MEE transport, Calbiochem®
別名:
Glutathione Monoethyl Ester, γ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE
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この商品について
実験式（ヒル表記法）:
C12H21N3O6S
CAS番号:
分子量:
335.38
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.77
Assay:
>90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
製品名
Glutathione Monoethyl Ester, Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH.
Quality Segment
assay
>90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
SC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)OCC
InChI
1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
InChI key
JKRODHBGNBKZLE-YUMQZZPRSA-N
General description
Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Effective transport of GSH-MEE has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. A protective agent against cellular damage, such as cataracts and mitochondrial degeneration.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Effective transport of GSH-MEE
Effective transport of GSH-MEE
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
Other Notes
Grattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.
Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 1
引火点 (F)
Not applicable
引火点（°C）
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
353905-50MG: + 353905-0MG: + 353905-30GM: + 353905-MG:
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