401477
IκB Kinase Inhibitor Peptide, Cell-Permeable
The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
別名:
IκB Kinase Inhibitor Peptide, Cell-Permeable, Ac- AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH2, Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH2
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この商品について
実験式（ヒル表記法）:
C138H229N37O45S
分子量:
3158.58
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
≥95% (HPLC)
Form:
lyophilized
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
PBS, pH 7.4: 1 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (<50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.
Biochem/physiol Actions
Cell permeable: no
Primary Target
LPS-induced IκB degradation by IKK in RAW 264.7 cells
LPS-induced IκB degradation by IKK in RAW 264.7 cells
Product does not compete with ATP.
Reversible: no
Target IC50: <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.
Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 1
引火点 (F)
Not applicable
引火点（°C）
Not applicable