407303
γ-Interferon, Mouse, Recombinant, E. coli
別名:
IFNG, Type II IFN
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この商品について
NACRES:
NA.77
UNSPSC Code:
12352202
Form:
liquid
Assay:
≥95% (SDS-PAGE)
description
Merck USA index - 14, 4992
Quality Level
assay
≥95% (SDS-PAGE)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
solubility
water: soluble
Protein ID accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
mouse ... Ifng(15978)
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General description
Note: 1 KU = 1000 units.
Research area: Immunology and Cytokines
Recombinant, mouse γ-interferon, consisting of 134 amino acids, expressed in E. coli as a single, non-glycosylated polypeptide.
Recombinant, mouse γ-interferon, consisting of 134 amino acids, expressed in E. coli as a single, non-glycosylated polypeptide.
Application
γ-Interferon has been used to assess the response of wild-type and cytosolic phospholipase A2 (cPLA2)-deficient cells to IFN-mediated signals. It has also been used to study the signaling pathway associated with IFN-γ and to explore the potential role of β-Arrestin1 in the dephosphorylation of signal transducer and activator of transcription 1 (STAT1).
Biochem/physiol Actions
Interferon-gamma (IFN-γ), a proinflammatory cytokine, exhibits a significant impact on innate and adaptive immunity in terms of combatting intracellular infections and facilitating tumor control. It has a significant impact on various immunological pathways. IFN-γ influences the following biological processes:
Antigen Processing and Presentation: IFN-γ enhances the expression of molecules involved in antigen presentation. This helps in the efficient activation of T cells, leading to the initiation of adaptive immunity.
Reactive Oxygen Species (ROS): IFN-γ stimulates the production of ROS by promoting the assembly of NADPH oxidase subunits. These ROS possess strong microbicidal effects, aiding in the defense against invading pathogens.
Autophagy: IFN-γ induces the expression of proteins involved in autophagy, facilitating the clearance of intracellular pathogens and contributing to immune defense.
Apoptosis: IFN-γ triggers apoptotic cell death by increasing the expression of molecules associated with the apoptotic pathway.
Cell Migration and Leukocyte Traffic: IFN-γ promotes the expression of chemokines and adhesion molecules, facilitating immune cell migration and contributing to the initiation of inflammatory responses.
Antiviral Mediators: By inducing the expression of various antiviral proteins, IFN-γ counteracts viral infections at multiple stages of the viral life cycle.
Antigen Processing and Presentation: IFN-γ enhances the expression of molecules involved in antigen presentation. This helps in the efficient activation of T cells, leading to the initiation of adaptive immunity.
Reactive Oxygen Species (ROS): IFN-γ stimulates the production of ROS by promoting the assembly of NADPH oxidase subunits. These ROS possess strong microbicidal effects, aiding in the defense against invading pathogens.
Autophagy: IFN-γ induces the expression of proteins involved in autophagy, facilitating the clearance of intracellular pathogens and contributing to immune defense.
Apoptosis: IFN-γ triggers apoptotic cell death by increasing the expression of molecules associated with the apoptotic pathway.
Cell Migration and Leukocyte Traffic: IFN-γ promotes the expression of chemokines and adhesion molecules, facilitating immune cell migration and contributing to the initiation of inflammatory responses.
Antiviral Mediators: By inducing the expression of various antiviral proteins, IFN-γ counteracts viral infections at multiple stages of the viral life cycle.
Physical form
In 10 mM PBS, pH 7.4.
Preparation Note
Dilute only in buffers containing protein such as 0.1% BSA.
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Zantl, N., et al. 1998. Infect. Immun. 66, 2300.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
407303-20RUG: + 407303-20UG:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis
Vignola MJ, et al.
The Journal of Biological Chemistry, 285(28), 1625-1635 (2010)
Impact of interferon-? on hematopoiesis
Bruin AMD, et al.
Blood, 24(16), 2479-2486 (2014)
Interferon-gamma (IFN-?): Exploring its implications in infectious diseases
Kak G, et al.
Biomolecular Concepts, 64-79, 9(1)-9(1) (2018)
Pei-Ju Liu et al.
Journal of the American Society of Nephrology : JASN, 33(11), 1989-2007 (2022-11-01)
Myo1e is a nonmuscle motor protein enriched in podocytes. Mutations in <i>MYO1E</i> are associated with steroid-resistant nephrotic syndrome (SRNS). Most of the <i>MYO1E</i> variants identified by genomic sequencing have not been functionally characterized. Here, we set out to analyze two
Christin Pelzel et al.
Molecular cell, 50(1), 149-156 (2013-04-16)
Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-γ (IFNγ) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. The inactivation of STAT1 occurs through tyrosine dephosphorylation by the tyrosine
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 407303-20UGCN | 04055977188233 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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