407306
γ-Interferon, Human, Recombinant, E. coli
description
Merck USA index - 14, 4992
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Recombinant, human γ-interferon expressed in E. coli. A multi-functional protein consisting of 144 amino acids. Exhibits antiviral and antitumor properties. Regulates the development of specific immune responses. Expressed in and purified from E. coli.
Biochem/physiol Actions
ED₅₀ = 0.5-3.0 ng/ml as measured by inhibition (cytostasis) of human WiDr cells.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
Sterile-filtered (0.22 µm) in 40 mM Tris-HCl, pH 7.4, carrier-free.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C). Do not store in glass vials without addition of carrier protein. Further dilute in low endotoxin medium or buffer containing FBS or tissue culture grade BSA.
Other Notes
Kohji, K., et al. 1994. J. Int. J. Cancer 58, 380.
Kolb, J.P., et al. 1994. J. Biol. Chem.269, 9811.
Müller, U., et al. 1994. Science264, 1918.
Zahedi, K., et al. 1994. J. Biol. Chem.269, 9669.
Shuai, K., et al. 1993. Science261, 1744.
Wilson, K.C., and Finbloom, D.S. 1992. Proc. Natl. Acad. Sci. USA89, 11964.
Meager, A. 1987. Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al., eds.) p. 129, IRL Press, Oxford.
Kolb, J.P., et al. 1994. J. Biol. Chem.269, 9811.
Müller, U., et al. 1994. Science264, 1918.
Zahedi, K., et al. 1994. J. Biol. Chem.269, 9669.
Shuai, K., et al. 1993. Science261, 1744.
Wilson, K.C., and Finbloom, D.S. 1992. Proc. Natl. Acad. Sci. USA89, 11964.
Meager, A. 1987. Lymphokines and Interferons, A Practical Approach (Clemens, M.J., et al., eds.) p. 129, IRL Press, Oxford.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
407306-100UG:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Christin Pelzel et al.
Molecular cell, 50(1), 149-156 (2013-04-16)
Signal transducer and activator of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-γ (IFNγ) stimulation, which results in the expression of genes with antiproliferative and immunomodulatory functions. The inactivation of STAT1 occurs through tyrosine dephosphorylation by the tyrosine
Johnathan Ho et al.
PLoS biology, 14(10), e2000117-e2000117 (2016-10-26)
STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IFN-independent activities. Here, we show that
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 407306-100UGCN | 04055977188257 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）