主要文書

すべての文書を表示

412510

IRE1 Inhibitor I, STF-083010

Name: IRE1 Inhibitor I, STF-083010
Brand: MM

The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.

別名:

IRE1 Inhibitor I, STF-083010, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

実験式（ヒル表記法）:

C₁₅H₁₁NO₃S₂

分子量:

317.38

UNSPSC Code:

51111800

NACRES:

NA.77

MDL number:

MFCD02332975

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

input

mammalian sample(s)

solubility

DMSO: 100 mg/mL, clear, yellow

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(\N=C\c2c3c(ccc2O)cccc3)c1[s]ccc1

InChI

1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+

InChI key

TVIVJHZHPKNDAQ-MHWRWJLKSA-N

詳細

General description

A cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010. Blood117, )1311.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

保管分類

11 - Combustible Solids

WGK

WGK 3

引火点 (F)

Not applicable

引火点（°C）