444284
MMP-2/MMP-3 Inhibitor III, PD166793
The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
別名:
MMP-2/MMP-3 Inhibitor III, PD166793, (S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
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この商品について
実験式（ヒル表記法）:
C17H18BrNO4S
CAS番号:
分子量:
412.30
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 40 mg/mL, ethanol: 40 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N[C@@H](C(C)C)C(=O)O)c1ccc(cc1)c2ccc(cc2)Br
InChI
1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
InChI key
GJOCABIDMCKCEG-INIZCTEOSA-N
General description
A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
MMP-2, -3, and -13
MMP-2, -3, and -13
Product does not compete with ATP.
Reversible: no
Target IC50: 47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Paolocci, N., et al. 2006. J. Pharm. Exp. Ther.317, 506.
Zhou, Y.P., et al. 2005. Diabetes54, 2612.
Peterson, J.T., et al. 2001. Circulation103, 2303.
Spinale, F.G., et al. 1999. Circ. Res.85, 364.
Zhou, Y.P., et al. 2005. Diabetes54, 2612.
Peterson, J.T., et al. 2001. Circulation103, 2303.
Spinale, F.G., et al. 1999. Circ. Res.85, 364.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
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