主要文書

すべての文書を表示

5.05206

Photochromic TrpA1 Channel Activator, Optovin

Name: Photochromic TrpA1 Channel Activator, Optovin
Brand: MM

別名:

Photochromic TrpA1 Channel Activator, Optovin, (E)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one, PDSP 22594, Transient Receptor Potential A1 Ion Channel Activator I, TrpA1 Channel Activator I

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

実験式（ヒル表記法）:

C₁₅H₁₃N₃OS₂

CAS番号:

348575-88-2

分子量:

315.41

MDL number:

MFCD02219276

UNSPSC Code:

41106609

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

assay

≥95% (HPLC)

Quality Segment

100

form

powder

potency

2 μM EC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

SMILES string

S1C(=S)NC(=O)C1=Cc2c([n](c(c2)C)c3cnccc3)C

InChI

1S/C15H13N3OS2/c1-9-6-11(7-13-14(19)17-15(20)21-13)10(2)18(9)12-4-3-5-16-8-12/h3-8H,1-2H3,(H,17,19,20)

InChI key

YISGMOZSGOGYOU-UHFFFAOYSA-N

詳細

General description

A rhodanine derivative that acts as a reversible, photoactivated (λ_{max = 415 nm), and highly TrpA1-selective channel activator, presumably by a light-activated cysteine alkylation mechanism via the α,β-unsaturated alkene group of Optovin rhodanine moiety, and enables light-induced primary murine DRG calcium response in a TrpA1-dependent and HC-030031- (Cat. No. 648485) blockable manner, allowing light-induced activation only in hTrpA1-expressing, but not TrpV1- or TrpM8-expressing, HEK293T transfectants. Its in vivo efficacy is demonstrated in light-induced zebrafish motor activity (EC₅₀/EC_max = 2 µM/3 µM; with >1.6 µW/min 387-405 nm excitation) and low power 405 nm laser-induced head shake/twitch response in mice (0.3 µmol Optovin/20 uL DMSO/ear applied atopically before laser illumination). Exhibits little or no inhibitory activity toward hERG or a panel of 50 human and rodent CNS receptors, channels, and transporters.}

Biochem/physiol Actions

Primary Target
TrpA1

Packaging

Packaged under inert gas

Other Notes

Kokel, D., et al. 2013, Nat. Chem. Biol.9, 257.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c