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5.05277

GTS-21 Dihydrochloride (DMBX-A)

Name: GTS-21 Dihydrochloride (DMBX-A)
Brand: MM

別名:

GTS-21 Dihydrochloride (DMBX-A), E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3ʹ-bipyridine, DMBX-A, α7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21

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この商品について

実験式（ヒル表記法）:

C₁₉H₂₀N₂O₂ · 2HCl

CAS番号:

156223-05-1

分子量:

381.30

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00941364

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mM, H₂O: 100 mM

storage temp.

−20°C

SMILES string

[Cl-].[Cl-].n1cc(ccc1)C2=NCCC\C\2=C/c3c(cc(cc3)OC)OC.[H+].[H+]

InChI

1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;

InChI key

BXKYFUGAAFLYJL-BXGYHSFXSA-N

詳細

General description

A partial agonist selective for α7 nAChRs (EC₅₀ = 10 µM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer′s disease studies.

Biochem/physiol Actions

Primary Target
α7 nAChR

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kox, M., et al. 2011. Br. J. Anaesth.107, 559.
Kox, M., et al., 2011. Shock.36, 5.
Rosas-Ballina, M., et al. 2009. Mol. Med.15, 195.
Briggs, A., et al. 1997. Pharmacol. Biochem. Behav.57, 231.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c