5.05419
α,β-Methyleneadenosine 5′-triphosphate lithium salt
≥93% (HPLC), powder, P2X purinergic receptor agonist, Calbiochem®
別名:
α,β-methylene ATP, αβ-MeATP, αβ-methylene ATP, P2X purinergic receptor agonist, α,β-methylene ATP, α,β-Methyleneadenosine 5ʹ-triphosphate lithium salt
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この商品について
Assay:
≥93% (HPLC)
Form:
powder
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
製品名
α,β-methylene ATP,
assay
≥93% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 100 mg/mL
storage temp.
−20°C
SMILES string
[Li+].[P](=O)([O-])(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)[n]2c3ncnc(c3nc2)N)C[P](=O)(O[P](=O)(O)O)O
InChI
1S/C11H18N5O12P3.Li/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-29(19,20)4-30(21,22)28-31(23,24)25;/h2-3,5,7-8,11,17-18H,1,4H2,(H,19,20)(H,21,22)(H2,12,13,14)(H2,23,24,25);/q;+1/p-1/t5-,7-,8-,11-;/m1./s1
InChI key
NVHVREPTGDOYIC-YCSZXMBFSA-M
General description
A metabolically stable and selective P2X purinergic receptor agonist (pEC50 = 5.81) that is shown to be more potent than ATP. Elicits contractions in ileum through the release of endogenous acetylcholine, which can be blocked by tetrodotoxin (~1 mM). Shown to depolarize cells of the longitudinal muscle strips (~ 200 nM to 4 µM) that reaches a peak within 2-3 min after application and then decays to a steady level.
Biochem/physiol Actions
Primary Target
P2X
P2X
Reversible: yes
Other Notes
Sawyer, G.W., et al. 2000. Br. J. Pharmacol.129, 1458.
Komori, S., et al. 1988. Br. J. Pharmacol.94, 9.
Komori, S., et al. 1988. Br. J. Pharmacol.94, 9.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable