5.05758
Oxidized ATP (oATP)
≥97% (HPLC), Schiff-base-forming reagent, powder
別名:
Oxidized ATP (oATP), Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
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この商品について
実験式（ヒル表記法）:
C10H14N5O13P3
CAS番号:
分子量:
505.17
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
製品名
Oxidized ATP (oATP),
assay
≥97% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 50 mg/mL
storage temp.
−20°C
SMILES string
[Na].[P](=O)(O[P](=O)(OCC(OC([n]1c2ncnc(c2nc1)N)C=O)C=O)O)(O[P](=O)(O)O)O
InChI
1S/C10H14N5O13P3.Na/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20;/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);
InChI key
KOCWSVPHHGJWHA-UHFFFAOYSA-N
General description
Oxidized ATP (oATP) is a Schiff-base-forming reagent is utilized as an antagonist at the P2X7 receptor for several years. It was initially identified as an affinity reagent for nucleotide-binding proteins. oATP reduces nuclear factor kappa B (NF-κB) activation and IL-8 release in cells lacking P2X7R, suggesting that some anti-inflammatory effects of oATP may not be solely attributed to the blockade of the P2X7R. This effect of oATP is reminiscent of the action of other natural or synthetic Schiff-base-forming reagents with immunomodulatory activity.
Application
Oxidized ATP (oATP) may be used to study its effects on the proinflammatory responses in human umbilical vein endothelial cells (HUVEC), HEK293 cells, and 1321N1 astrocytes that lack expression of P2X7R.
Biochem/physiol Actions
Reversible: no
Other Notes
Vergani, A., et al. 2013. Diabetes62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946.
Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.
DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946.
Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。