主要文書

すべての文書を表示

5.05855

Adenovirus Proteinase Inhibitor

Name: Adenovirus Proteinase Inhibitor
Brand: MM

powder, ≥90% (HPLC)

別名:

Adenovirus Proteinase Inhibitor, NSC 37249, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor, AVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide

で組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

実験式（ヒル表記法）:

C₄₀H₅₈N₄O₄S

CAS番号:

2907-88-2

分子量:

690.98

MDL number:

MFCD31800417

UNSPSC Code:

12352202

NACRES:

NA.21

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

製品名

Adenovirus Proteinase Inhibitor, NSC 37249,

assay

≥90% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

5% TFA in ethanol: 5 mg/mL, DMSO: insoluble

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(c4ccc(cc4)NC(=O)CN(C6CCCCC6)C5CCCCC5)c1ccc(cc1)NC(=O)CN(C3CCCCC3)C2CCCCC2

InChI

1S/C40H58N4O4S/c45-39(29-43(33-13-5-1-6-14-33)34-15-7-2-8-16-34)41-31-21-25-37(26-22-31)49(47,48)38-27-23-32(24-28-38)42-40(46)30-44(35-17-9-3-10-18-35)36-19-11-4-12-20-36/h21-28,33-36H,1-20,29-30H2,(H,41,45)(H,42,46)

InChI key

JQYJJPSTWWRURQ-UHFFFAOYSA-N

詳細

General description

A sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus AVP, the cysteine proteinase critical for virion assembly and maturation, by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (K_i = 150 nM) and AVP-pVIc substrate-binding site (K_i = 400 nM), blocking not only AVP-pVIc active complex formation/AVP activation (IC₅₀ = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM), but also AVP-pVIc active complex catalytic activity (IC₅₀ = 490 nM; [substrate] = 5 µM). Does not affect the activity of the serine protease trypsin or the cysteine protease papain even at concentrations as high as 10 µM.

Biochem/physiol Actions

Primary Target
AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket

Reversible: yes

Secondary Target
AVP-pVIc substrate-binding site

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

McGrath, W.J., et al. 2013. FEBS Lett.587, 2332.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c