5.05877
(S)-(-)-Raclopride
別名:
(S)-(-)-Raclopride, Dopamine Receptor D2 Antagonist, (S)-Raclopride, Raclopride
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この商品について
実験式（ヒル表記法）:
C15H20Cl2N2O3
CAS番号:
分子量:
347.24
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mM, ethanol: 25 mM
storage temp.
2-8°C
SMILES string
Clc1c(c(c(c(c1)Cl)O)C(=O)NC[C@@H]2N(CCC2)CC)OC
InChI
1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1
InChI key
WAOQONBSWFLFPE-SECBINFHSA-N
General description
D2-like dopamine receptor antagonist targeting D2R (pKi =8.0), D3R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D2 like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D2 Receptor selectivity in various preps shows IC50 values around 32 nM.
Biochem/physiol Actions
Reversible: yes
Other Notes
Dang, Y. H. et al. 2010. Neurosci.169, 1872.
Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.
Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable