5.05986
SR-95531
≥98% (HPLC), solid, GABAA receptor antagonist, Calbiochem®
別名:
SR95531 (Gabazine), GABA A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531
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この商品について
実験式（ヒル表記法）:
C15H17N3O3 · xHBr
CAS番号:
分子量:
287.31 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
製品名
SR95531 (Gabazine),
assay
≥98% (HPLC)
Quality Segment
form
solid
potency
440 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 25 mM
storage temp.
2-8°C
SMILES string
[Br-].[N+H2]=C1N(N=C(C=C1)c2ccc(cc2)OC)CCCC(=O)O
InChI
1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H
InChI key
GFZHNFOGCMEYTA-UHFFFAOYSA-N
General description
A selective, competitive antagonist of GABAA receptor (IC50 = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (Kb = 190 µM).
Biochem/physiol Actions
Primary Target
GABAA
GABAA
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable