5.06417
SB 242084 Hydrochloride
≥98% (HPLC), 5-HT2C receptor antagonist, solid
別名:
SB 242084 Hydrochloride, 5-HT 2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
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この商品について
実験式（ヒル表記法）:
C21H19ClN4O2 · xHCl
CAS番号:
分子量:
394.85 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
製品名
SB 242084 Hydrochloride,
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white to pale yellow, pale yellow
solubility
water: soluble
storage temp.
−20°C
SMILES string
Clc1cc2c(cc1C)CCN2C(=O)Nc3cnc(cc3)Oc4c(nccc4)C.Cl.Cl
InChI
1S/C21H19ClN4O2.2ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);2*1H
InChI key
GCMNSEILNIPNSX-UHFFFAOYSA-N
General description
A selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.
Biochem/physiol Actions
Primary Target
5-HT2C
5-HT2C
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther.342, 761.
Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111.
Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1.
Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
Burghardt, N. S., et al. 2007. Biol Psychiatry62, 1111.
Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther.23, 1.
Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable