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5.08316

CTAP

Name: CTAP
Brand: MM

別名:

CTAP, µ opioid receptor antagonist, CTAP

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この商品について

実験式（ヒル表記法）:

C₅₁H₆₉N₁₃O₁₁S₂

CAS番号:

103429-32-9

分子量:

1104.30

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00671434

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

assay

≥95% (HPLC)

Quality Segment

100

form

solid

potency

3.5 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

water: soluble

storage temp.

−20°C

SMILES string

S1SC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C1(C)C)C(=O)N[C@@H]([C@H](O)C)C(=O)N)[C@H](O)C)CCCN=C(N)N)Cc4c5c([nH]c4)cccc5)Cc3ccc(cc3)O)NC(=O)[C@H](N)Cc2ccccc2

InChI

1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1

InChI key

OFMQLVRLOGHAJI-FGHAYEPSSA-N

詳細

General description

A highly potent octapeptide that acts as a selective and brain penetrating bioavailable µ opioid receptor antagonist (IC₅₀ = 3.5 nM). Used in studies of reward systems and additions.

Biochem/physiol Actions

Primary Target
u Opioid receptpr

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (2-7 disulfide bond)

Perry, C., et al., 2013. Behav. Neurosci.127, 535.
Burkett, J. et al. 2011. Neuropsychopharm.36, 2200.
Steinmiller, L., et al., 2008. Psychopharmacol. (Berl).195, 497.
Sterious, S., et al., 2003. J. Pharmacol. Exp. Ther.304, 301.
Abbruscato, T., et al. 1997. J. Pharmacol.280, 402.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 3

引火点 (F)

Not applicable

引火点（°C）