5.08438
Lamellipodial Growth Promoter, C8N6 BPA Polyamine
別名:
Lamellipodial Growth Promoter, C8N6 BPA Polyamine, Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
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この商品について
実験式（ヒル表記法）:
C20H48N6 · 6HCl
CAS番号:
分子量:
591.40
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352116
Assay:
≥95% (NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥95% (NMR)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
water: 100 mg/mL, DMSO: 50 mg/mL
storage temp.
2-8°C
General description
A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Packaging
Packaged under inert gas
Other Notes
Nedeva, I., et al. 2013. Nat. Commun.4, 2165.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。