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5.30961

TAZ Activator, IBS008738

Name: TAZ Activator, IBS008738
Brand: MM

別名:

TAZ Activator, IBS008738, (4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone, Transcriptional Co-activator with PDZ-binding Motif (TAZ) Activator, WWTR1 Activator

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この商品について

実験式（ヒル表記法）:

C₂₂H₂₂N₄O₂

CAS番号:

385425-03-6

分子量:

374.44

UNSPSC Code:

12352200

NACRES:

NA.77

PubChem Substance ID:

6160351

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

assay

≥98% (HPLC)

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 50 mg/mL

storage temp.

−20°C

SMILES string

CC1=CC=C(C=C1)N2C=NC(=C2C(=O)C3=CC=CC=C3)N=CN4CCOCC4

InChI

1S/C22H22N4O2/c1-17-7-9-19(10-8-17)26-16-24-22(23-15-25-11-13-28-14-12-25)20(26)21(27)18-5-3-2-4-6-18/h2-10,15-16H,11-14H2,1H3

InChI key

UCDKLMTYEDPEMY-UHFFFAOYSA-N

詳細

General description

A benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Packaging

Packaged under inert gas

Other Notes

Yang, Z., et al. 2014. Mol. Cell. Biol.34, 1607.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c